10.1074/JBC.275.10.7337 112 ShenQ.YeW.HuX.ZhaoC.ZhouL.ZhuX
Media hype (the Hollywoods worst-kept secret, King Kong of weight loss, etc.) has spotlighted GLP-1 drugs, but the medical issue is delayed gastric emptying that, in some patients, is linked to gastroparesis-like symptoms
doi:10.5962/bhl.title.51971
In the context of GLP-1 agonists, this means that healthcare providers may adjust the dosage, combine treatments, or incorporate lifestyle modifications to optimize results for each person
Many patients blame themselves for lack of discipline when the real issue is that their metabolism is underpowered
73 In summary, peripheral administration of GLP-1RAs either acts directly on the hypothalamus and hindbrain, which lack BBB, or directly crosses the BBB into CNS, which are then projected to other key feeding areas of the brain (Figure 6)