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These effects are usually mild to moderate, occur most frequently when starting treatment or increasing doses, and often improve over time

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However, this same action can lead to a range of digestive symptoms that affect a significant proportion of patients

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Part of the reason could be that arbutin does not form hydrogen bonds with the residues in the C1 region (Table 2).The RMSF values of the residues surrounding Arbutin_c and Arbutin_d were generally low

[DOI] [PMC free article] [PubMed] [Google Scholar] Leiter LA, Teoh H, Kallend D, Wright RS, Landmesser U, Wijngaard PLJ, Kastelein JJP, Ray KK, 2018