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Specifically, sphingomyelinases (also known as sphingomyelin phosphodiesterases) catalyze the cleavage of sphingomyelin, generating phosphocholine and ceramide
Most importantly, the trial data used to fit their model only extended to 52 weeks after cessation
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Disruption of ERAD in this context impairs leptin responsiveness, resulting in hyperphagia, excessive weight gain, and heightened susceptibility to diet-induced obesity in mice
Therefore, the overall benefit-risk profile remains strongly favorable for most patients with type 2 diabetes
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