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DES(1-3) IGF-1 is a truncated variant missing the first three N-terminal amino acids (Gly-Pro-Glu), which also reduces IGFBP binding but through a different structural mechanism removal of the N-terminal tripeptide rather than charge substitution

Tandem-cleavage linkers improve the in vivo stability and tolerability of antibodydrug conjugates

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NF-kB p65 and SIRT1 % area immunostaining expressions in different groups liver tissues are shown in Figure 9

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