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Patients with type 5 Bartter syndrome initially present with hypocalcemia with tetany and low levels of parathyroid hormone, PTH

For participants with obesity and T2D, the higher dose produced an average weight loss of 13%, compared with 10% on 2.4 mg and 3.9% on placebo, alongside meaningful reductions in blood sugar levels and waist circumference

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Any shorter and weekly dosing wouldnt work reliably