The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake
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Bioavailability of B12 is dependent on specific conditions in the digestive tract
Communication could have been better but, the product works
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While its true that receptor density can change due to various factors, its an oversimplification to suggest that this change is the direct cause of increased pain or sensations in B12-treated individuals