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The rationale and design across its trials were described by Giblin and colleagues in Diabetes, Obesity and Metabolism in 2026 (PMID 41090431)

Gimbrone MA Jr, Topper JN, Nagel T, Anderson KR, Garcia-Cardena G

Quality statement 1: Referral Rheumatoid arthritis in over 16s (QS33)

Retatrutide versus semaglutide Semaglutide (Wegovy, Ozempic) activates only GLP-1 receptors

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Within authorised clinical trials, storage conditions, in-use stability, and handling requirements for retatrutide are defined by the trial sponsor's protocol and IMP dossier