[10] With a p K a of 31, the sulfone can be deprotonated with sodium amide
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Internalization experiments validated receptor-mediated endocytosis, resulting in cytoplasmic accumulation, while in vivo imaging demonstrated significant tumor targeting and retention, with aptamer Levels in tumors being 50 to 1000 times greater than in other tissues
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10.3390/nu13010085 362 PavanS.PrabhuA