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While that is less than the more than 20% seen with some injectable options, Egan said the results are still meaningful

In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise

This interview has been edited and condensed for clarity .

Most protocols start at a low dose and increase at regular intervals (typically every 4 weeks)

Gubras biopsy-confirmed GAN DIO-MASH mouse model offers a powerful tool for studying MASH progression and therapeutic interventions