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This activation initiates signaling via the docking protein fibroblast growth factor receptor substrate 2 (FRS2) and the Src homology-2 domain-containing protein tyrosine phosphatase-2 (Shp2), resulting in the phosphorylation of extracellular signal-regulated kinases (ERK) 1/2

These results furnish evidence that the recruitment and/or retention of PDS5B to stressed replication forks is dependent on its DNA binding activity

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