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Guillin OM, Vindry C, Ohlmann T, Chavatte L

International journal of physiology, pathophysiology and pharmacology, 10(3), 132138

The underlying pathology differs from what many people assume

Intervention studies employing dopaminergic neuron-targeted PGC-1 overexpression via adeno-associated viral vectors reveal enhanced redox homeostasis in striatal neurons and marked attenuation of programmed dopaminergic cell death, establishing this transcriptional coactivators neuroprotective capacity in PD pathophysiology (Wang et al., 2019c)