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Evidence suggests that KP dysregulation may contribute to MDD by disrupting the balance between excitatory and inhibitory neurotransmission

Genes with a Benjamini-Hochberg adjusted p-value 1.5 were considered differentially expressed

J Neuroimmune Pharmacol

Inflammation also shifts tryptophan metabolism away from serotonin to neurotoxic kynurenine pathway metabolites, like quinolinic acid, and disturbs neurotransmission and thus plays a role in depressive symptoms (Chen et al., 2021

Dey S, Buwa V (2022) Identification of potential Cox-2 inhibitors from phytochemical constituents of Indian Garam Masala using in silico analysis

10.1186/1756-9966-27-44 J