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the typical size of the tumor at diagnosis is around 5 cm Common locations of the tumors include the spinal nerves, nerves of the GI tract, soft tissues of the arms, legs, and trunk They can also occur in other body parts such as the bone (Psammomatous Melanotic Schwannoma of Bone), liver (Psammomatous Melanotic Schwannoma of Liver), heart (Psammomatous Melanotic Schwannoma of Heart), and bronchus (Psammomatous Melanotic Schwannoma of Bronchus) Signs and symptoms of underlying Carney complex are observed in individuals with the disorder

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Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models

The journal of toxicological

Kwok T, Lee J, Ma R, Wong S, Kung K, Lam A, Ho C, Lee V, Harrison J, Lam L

Calculations are shown for both the 5 days/week and 3 times/week schedules