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Foresman JB, Fox DJ

Systemic Implications If an 85 mg/day human protocol were sustained over 8 weeks to match the murine intranasal timeline, it would cross into a biochemically hazardous profile: Hepatic Accumulation: The primary adverse effect of chronic copper toxicity is hepatotoxicity

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You have triggered the copper uglies: MMP overexpression from copper overload that degrades collagen instead of building it