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It's an analogue of gastric inhibitory polypeptide (GIP), which is a human hormone that stimulates the release of insulin from the pancreas

The dynamic roles of the bladder tumour microenvironment

Retatrutides triple agonism GLP-1, GIP, and glucagon receptor activation enhances insulin secretion, improves sensitivity and increases energy expenditure, contributing to HbA1c reductions

Patient had protracted coma, high ammonia levels, cerebral oedema on CT, and developed seizures on day 3 of admission

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Notably, GLP-1 RAs have been shown to modulate immune activity by enhancing NK cell cytotoxicity