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While indirect cross-trial comparisons can be hypothesis-generating, they are no replacement for the gold standard of randomized head-to-head clinical trials, a Lilly spokesperson tells SELF

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The exact timeline depends on your dose escalation schedule , as the starting dose of 2mg produces minimal appetite effects and meaningful suppression begins at 4mg and above

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doi: 10.1111/j.1464-5491.2012.03652.x 60 SinghSChangH-YRichardsTMWeinerJPClarkJMSegalJB