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Conclusion In this network meta-analysis, tirzepatide was associated with significant reductions in MACE, CV mortality, all-cause mortality, non-fatal MI, and non-fatal stroke compared with placebo in the class-level analysis

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The article ties this to its wider point that rapid weight loss can unmask or worsen existing kidney disease

Disruptions in Mn balance impact not only local processes but also broader systemic networks, emphasizing its dual nature as both a necessary micronutrient and a potential neurotoxin