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Human research demonstrated that methylcobalamin supplementation in patients with inadequate B12 levels improved CD4/CD8 ratio and NK cell activity, and augmented CD3-CD16+ cells, suggesting an important role in cellular immunity.[14] In other research, among homologues studied, methylcobalamin was shown to have the strongest antibody production enhancement on an in vitro system.*[15]
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Madras BK, Miller GM, Fischman AJ
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The exact prevalence of vitamin B12 deficiency in industrialised countries is unknown
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