Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations
In preclinical cell culture assays measuring dendritic arborization and synaptic outgrowth, Dihexa demonstrated neurotrophic activity estimated to be up to seven orders of magnitude 1,000,000 times more potent than Brain-Derived Neurotrophic Factor (BDNF) on a molar basis
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision
Whole-cell patch-clamp recordings were performed on mRFP--actin-transfected hippocampal neurons to measure miniature excitatory postsynaptic currents (mEPSCs), reflecting synaptic activity [2]
References (For Scientific Context) Benoist CC et al., , 2014 Journal of Pharmacology and Experimental Therapeutics Wright JW et al., , 2015 Journal of Alzheimers Disease Sun X et al., , 2021 Brain Sciences Reviews There are no reviews yet
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