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This could be because it stays in the body longer and continues to activate the receptors over time, which is especially important in preventing severe hypoglycemia

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Using the same exact spot every time can lead to a condition called lipohypertrophy , which is a buildup of fatty tissue under the skin

In a study with 28 days of exendin-4 treatment in mice with diet-induced obesity, the initial transient reduction in food intake disappeared over time [23]