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Prescribers select it partly because pituitary-driven GH release preserves the normal pulsatile pattern that endogenous GH secretion follows

Mendoza et al., 2024

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Activity-driven local ATP synthesis is required for synaptic function

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The NO pathway is especially important in endothelial cells, as PKA activates NO synthase (NOS), which can produce more nitric acid and does result in reduced small intestine, large intestine, and colon motility