A flavonoid metabolite isolated from Scutellaria baicalensis Georgi was administered intragastrically to mice with asthma, the inhibition of STAT3 in lung tissue, the promotion of FOXP3 in lung tissue, the reduction in serum IgE, IL-17 A, and IL-6 secretion in BALF, the promotion of IL-10 secretion, and the improvement of Th17/Treg immune imbalance were observed (Xu et al., 2017)
Future in vitro studies to test candidate therapeutic compound in COVID-19 should deploy standardized assays, for example, Vero cells that can competently replicate and isolate the virus readily, whereas in vivo studies should utilize transgenic mice and Syrian hamsters, or cats and ferrets if opting for larger experimental animals
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
