This contributes to adipose tissue dysfunction, whereas WAT inflammation and oxidative stress supervene, promoting the release of pro-inflammatory adipokines, leptin and adiponectin, along with enormous levels of cytokines (IL-6, IL-1b, TNF-) and NF-B activation, all ending in a cycle of sustained systemic insulin-resistant state [36,98,99,100]
However, preliminary data suggests: Tirzepatide: Approximately 33-39% of weight lost was lean mass in SURMOUNT trials Retatrutide: Early data suggests potentially better lean mass preservation, possibly due to glucagon's effects on protein metabolism Regardless of which medication you use, resistance training and adequate protein intake (1.0-1.2g per kg body weight daily) are recommended to minimize muscle loss during treatment
It is the leading cause of liver transplant waitlist additions
Summary: The optimal timing for GLP-1 injections depends on the specific formulation, with once-weekly products like semaglutide and dulaglutide administered at any time of day, whilst consistency and adherence are the most important factors
ZOA gains +19pp, Bang gains +21pp, Reign gains +20pp, PRIME gains +17pp
If you notice any abnormalities, do not use it
