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Fasting glucose, insulin levels, GLP-1 receptor signaling capacity, and baseline BMI all contribute to treatment response variability

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To put that into perspective, the average weight loss with Wegovy (semaglutide 2.4 mg) is around 17.5% over 68 weeks, and with Mounjaro (tirzepatide 15 mg), around 20% over 72 weeks

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Women of childbearing potential should discuss pregnancy planning, as these medications are not recommended during pregnancy and should be discontinued at least 2 months before a planned pregnancy