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Melatonin redirects cellular metabolism from glycolysis and oxidative phosphorylation towards the NADPH-generating pentose phosphate pathway, enhancing NRF2 activity and glutathione biosynthesis

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REIMAGINE 2 was a 68-week efficacy & safety trial investigating once weekly SC CagriSema, a fixed-dose combination of the Amylin receptor agonist, cagrilintide, & GLP-1RA, Semaglutide, compared to Semaglutide & placebo, the study enrolled 2,728 patients with type 2 diabetes inadequately controlled with metformin with or without an SGLT2I

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28 , 721736.e726 (2018)