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The combination of GLP1RAs and metformin resulted in significant reductions in body weight (mean difference [MD]=-1.37 kg, 95% CI [-2.07, -0.67]

8 mm: May require a skin pinch or 45-degree angle to avoid intramuscular injection in leaner individuals

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Current data does not establish a definitive causal link between GLP-1 medications and bone loss , but several studies have examined potential associations

Ensure youre using pharmaceutical-grade therapies