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PCNA positive cells were observed in multi-layered epithelium in the galactose diet-loaded model, suggesting that abnormal cell proliferation is involved in cataracts 71

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10.1016/j.toxlet.2008.06.866 22

Future work may consider the use of 1) a higher dosage of ALCA, 2) smaller test meals, and 3) the use of metabolically normal test subjects in order to further determine the potential antioxidant benefits of ALCA in relation to postprandial oxidative stress and associated biomarkers

Controversially to the evidence that CBS is linked to carcinogenesis, a study presents CBS as a tumor suppressor gene, claiming that in gastric and colorectal cancer the expression of CBS is inhibited by DNA methylation in association with KRAS mutations (88)