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We also tested a non-CRC model, the osteosarcoma U2OS cell line, which is wild-type for APC, KRAS and p53, and confirmed a similar 5FU-driven change in mitochondrial mass and morphology (Extended Data Fig

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doi:10.1016/j.bbacli.2014.12.005

[15]Rashid A, Schutte BJ, et al

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