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Despite all advances in neuroscience in recent decades, age-associated cognitive decline resulting from neurodegenerative processes in the brain remains a challenge for researchers and clinicians due to the highly complex nature of its pathogenesis

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BBB permeability can be visualized directly in AD patients using imaging technologies including dynamic contrast-enhanced and arterial spin labeling magnetic resonance imaging, and recent studies employing these techniques have shown that subtle changes in BBB stability occur prior to deposition of the pathological hallmarks of AD, senile plaques, and neurofibrillary tangles