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Applying an ice pack or cold compress may also bring relief

These stages are marked by a substantial increase in ATP demand within granulosa cells and oocytes

Inflammatory cytokines IL-1 and IL-18 present in the ovarian tissue and FF in PCOS patients alter the follicular microenvironment by binding to receptors like IL-1R and TLR4 on the GCs, activating NF-B, which subsequently translocates into the nucleus (50)

By addressing underlying physiological processes, peptide therapy encourages a more balanced and fulfilling life

The safety window is unusually wide

Taken together, these insights suggest that polyphenols are unlikely to compete directly with modern biologics or small-molecule inhibitors as systemic therapies, but they retain value as adjunctive or topical interventions, particularly when formulated in advanced nanocarrier platforms that can improve skin penetration and local retention [39]