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A 2024 study published in JAMA Ophthalmology found an increased risk of NAION for those taking semaglutide medications

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Prins ND, Scheltens P

To account for the pronounced heterogeneity of the preclinical evidence base, specific inclusion criteria for preclinical studies were defined as follows: (1) Model Type: utilization of established in vivo models (e.g., transgenic AD models like APP/PS1 or 3xTg-AD, neurotoxin-induced PD models, middle cerebral artery occlusion for ischemia, or high-fat diet for metabolic dysfunction) or relevant in vitro neuronal/glial cell lines

10.1016/j.ijbiomac.2020.04.073 351 WangZ.LiK.XuQ.FuG.YangW