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This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway

Two microliters of either LV-shBDNF (treatment) or LV-shSCR (control) were microinjected bilaterally into the specific hippocampal subregions over 4 min using a dual channel MAB 40 microdialysis pump (Microbiotech/SE AB, Stockholm, Sweden)

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