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However, insulin elevation from food intake activates opposing lipogenic (fat-storing) pathways that can blunt the peptides fat-mobilizing effects

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The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

What they did: Characterization of AOD-9604 in isolated rat adipocytes