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The kinetic data can be best explained by a ternary complex in which PfGrx recruits and activates GSH at the 1st glutathione-interaction site to facilitate the rate-limiting glutathionylation of roGFP2 WT (S 2 ) and its subsequent deglutathionylation in accordance with monothiol mechanism (iii) from Fig
These ROS are responsible for premature skin ageing and cell damage
PMID 20700719
Kenny FM, Iturzaeta N, Preeyasombat C, Taylor FH, Migeon CJ, Richards C
Han JC, Lawlor DA, Kimm SY