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Despite promising preclinical outcomes, their clinical translation is hindered by poor solubility, instability, and batch variability

Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2

The NIH reports that only about 10 micrograms of a 500-microgram oral supplement is actually absorbed in healthy people due to limitations of stomach acid and intrinsic factor