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Additionally, semaglutide slows gastric emptying, which prolongs the sensation of fullness after meals and reduces appetite through effects on appetite centers in the brain

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Selenium deficiency is also characterized by elevated levels of oxidative stress markers in the liver 21 , which significantly contribute to liver injury 17

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*Glutathione decline reference: Lang et al., J Lab Clin Med circulating glutathione levels decline approximately 30% by age 65 in healthy adults compared to younger adults.

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However, 32% still indicated an interest in trying these medications in the future

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Approval for the trials was granted by the Research Ethics Committee of the University of Tartu (270/T-13 and 236/T-10) and the Estonian Agency of Medicines (RKU-4/28 and RKU-4/18) and registered at Clinicaltrials.gov ( NCT02089256 and NCT03160261)

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