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Proc Natl Acad Sci U S A 89: 8641-8645, 1992

Another meta-analysis of 7 trials with 10,793 participants reported a 20% decrease in DR with intensive glycemic control (0.80, 0.67 to 0.94

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Regarding medication management, for patients with clinical cardiovascular disease, a sodiumglucose cotransporter-2 (SGLT2) inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist with proven cardiovascular benefit is recommended