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Severe gastrointestinal adverse reactions may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment, requiring close monitoring of fluid status and kidney function

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Specific clinical features such as polyneuropathy have also been linked to Vit B12 deficiency specifically in context of intrajejunal levodopa therapy

[8] [1] The Summary of Product Characteristics (SmPC) for all GLP-1 receptor agonists contains warnings about pancreatitis risk

Statements Data availability statement The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author

Chronic hyperglycemia triggers oxidative stress predominantly through the impairment of endogenous antioxidant systems leading to uncontrolled buildup of reactive ROS and subsequent macromolecular damage