The company was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication
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Participants, drawn from health records of nearly 140,000 patients in Canada, were matched for socioeconomic status and a long list of conditions in addition to diabetes
Pigmentation-based circles are often the result of excess melanin production
These changes were statistically significant, and the direction of effect suggests possible neuroprotection, but the magnitude was very small (particularly if we compare these results to those in the Phase 3 trials of AD drugs that are now approved, such as lecanemab or donanemab) , the sample limited, and there is no evidence these shifts translate into meaningful clinical benefit
