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Front Pharmacol (2016) 7:105.10.3389/fphar.2016.00105 101 VolkowNDWangG-JBalerRD

There is four decades of published research behind it

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Wang R, Li Z, Liu S, Zhang D

Animal studies in diet-induced obesity models show tesofensine treatment produces selective reduction in adiposity with improvements in insulin sensitivity, reductions in plasma lipids, and decreased accumulation of abdominal and subcutaneous fat mass

While the medication's primary effect is on gastric emptying, it may theoretically influence intestinal transit as well, potentially altering the intestinal environment and affecting the normal balance of digestive secretions