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PDE-5 inhibitors include: 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulphonyl)phenyl]-1-methyl-3-n- -propyl-1 ,6-dihydro-7H- pyrazolo[4,3-d]pyrimidin-7-one (sildenafil), also known as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3- propyl-1 R-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulphonyl]-4-methylpiperazine (see EP-A- 0463756 and U.S

DPP-4 is a proteolytic glycoprotein that removes the two N-terminal amino acids of small peptides when the second amino acid from the N-terminal side is alanine or proline [12]

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