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Mature islet cells lack the expression of YAP, while overexpression of YAP in islets is associated with proliferative and antiapoptotic effects

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mTOR is induced by Flt3 ligand (Flt3L) and is necessary for the Flt3L-driven development of DCs [100], and mTOR inhibits IL-1 production to impede DC maturation and the ability to stimulate effector T cell responses

The available data therefore suggests that GLP1 receptorinduced Ca 2+ responses represent a composite readout of activation of G s in particular, G q to a variable degree and possibly other G protein subunits

2010;154C:46976