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As for Polyphenol Booster, it contains: Pomegranate extract (375mg) , shown in a 2022 study to increase short-chain fatty acids and regulate GLP-1 secretion at 375mg doses,32 while a 2025 study found that pomegranate in general can help proliferate beneficial bacteria, including Akkermansia 33 Grape seed extract (275mg) , which produces a significant prebiotic effect on Akkermansia , as in a 2021 study that used 200mg doses34 Green tea extract (225mg) , which also favors Akkermansia proliferation,35 potentially at doses as low as around 50mg in a 150lb human (as suggested by mouse studies)36 All very well-dosed to support Pendulums probiotic supplements
One article outlined 25-30% of a 1600 kcal diet, which works out to 100-120 g/day of nutritional protein (Sievenpiper et al 2026)
This keeps tissue hydrated and comfortable, removing one barrier to desire
Most trials showing benefit used multi-strain formulations alongside caloric restriction, making it difficult to isolate probiotic effects
Appetite suppression becomes noticeable in weeks 2-4 for most people
Does retatrutide increase metabolism
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