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Many women notice weight gain, particularly around the abdomen, increased insulin resistance, unfavourable changes in cholesterol levels, and a higher risk of developing type 2 diabetes

Am J Physiol Endocrinol Metab 2015;309:E1008E1018 [DOI] [PubMed] [Google Scholar] 25

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When these signs are ignored, they can escalate into persistent redness, itching and burning, visibly dilated capillaries, papules, pustules, and acne-like spots