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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve

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The key insight: AOD-9604 added roughly 40-50% more fat loss on top of what diet and exercise produced

Content is updated for FY2026 ICD-10-CM (effective October 1, 2025)

Ferra F, Albani A, Ciresi A, Giordano C, Cannav S

About the need to monitor renal function, calcium, phosphorus, aluminum, and vitamin A levels in patients with renal impairment