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4 Effects on Body Weight and Adiposity SGLT2 inhibitors directly cause body weight loss via glucose excretion (calorie loss) in the kidneys

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Oral semaglutide (Rybelsus): The starting dose is 3 mg once daily for 30 days, followed by an increase to 7 mg or higher based on the doctor's guidance

Observational data and post-marketing surveillance provide signals that merit attentive monitoring, especially in individuals with a history of mood disorders or prior suicidality