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Reported pharmacological activities of bis-benzylisoquinoline alkaloids majorly including antimalarial, anti-inflammatory, anticancer, immunosuppression and anti-hepatitis activities (

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179 Approximately 90 percent of the filamin in resting platelets interacts with the cytoplasmic tail of the GPIb subunit of the GPIb-IX-V complex via a binding site in filamins second rod domain (repeats 17 to 20)

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