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Some patients respond better to one GLP-1 drug than another due to genetic variation in GLP1R gene expression or differences in how their bodies metabolize each compound

Because semaglutide reduced the risk of MACE irrespective of baseline kidney function and damage, it is of interest to evaluate if semaglutide can provide consistent effects on hard kidney-related outcomes (kidney failure, 50% decline in eGFR from baseline, or CV or kidney-related death) in the FLOW trial

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Its a move that may not be surprising, considering the impact of blockbuster weight-loss drugs and the consumer shift toward longevity-supporting measures

[DOI] [PubMed] [Google Scholar] 80.El-Hafidi M., Franco M., Ramrez A.R., Sosa J.S., Flores J.A.P., Acosta O.L., Salgado M.C., Cardoso-Saldaa G