This is more likely if you take blood pressure medication, take diuretics, become dehydrated, or experience vomiting or diarrhea
Previous animal studies have shown that the intraperitoneal administration of various TRPV1 antagonists results in hyperthermia 42
Some researchers find that starting at even lower doses than the clinical trial protocols and escalating more slowly can reduce the severity of gastrointestinal symptoms
People interested in investigational access should look for properly registered trials rather than informal sources
Mathew B, Chennakesavalu M, Sharma M, Torres LA, Stelman CR, Tran S, et al
"Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials"