Mechanistically, GLP-1R activation alleviates OA by fostering chondrocyte anabolic metabolism while inhibiting catabolism, safeguarding chondrocytes from endoplasmic reticulum stress and apoptosis, and displaying anti-inflammatory and antioxidant properties [15,16,17]
Because GIPR activation is glucose-dependent, this entire cascade engages fully only when blood glucose exceeds approximately 5.6 mmol/L (100 mg/dL), which explains the low hypoglycemia rate observed in SURPASS trials even at the 15 mg dose [6]
Slow dose titration helps minimize discomfort
The key is to choose an approach that fits your lifestyle and preferences, ensuring consistency over time
With GLP-1 therapy, clinicians give you a medication called a GLP-1 agonist
We have data in mice that suggest that things are not as straightforward as they might seem. Medical News Today spoke with Seth Kipnis, MD, FACS, FASMBS, director of bariatric and robotic surgery at Hackensack Meridian Jersey Shore University Medical Center in New Jersey, about this study, who commented that a drop in lean muscle mass is expected
